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Nolvadex is a prescription medicine used to treat the symptoms of Breast Cancer. This medicine may be used alone or with other medications.

Nolvadex belongs to a class of drugs called Antineoplastics, Estrogen Receptor Antagonists.

It is not known if Nolvadex is safe and effective in children.

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What are the possible side effects of Nolvadex?

Nolvadex may cause serious side effects including:

vision changes,
eye pain,
easy bruising or bleeding,
mood changes,
swelling of the ankles or feet, and
unusual tiredness

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why not take it?

Pregnancy.

· Breastfeeding.

· Hypersensitivity to the active substance or to any of the excipients listed in section List of excipients .

· St. John’s Wort ( Hypericum perforatum ) should not be used in conjunction with Nolvadex.

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Posology and method of administration

Dosage

· In the adjuvant treatment indication, the recommended dose is 20 mg per day, in one or two doses. It is currently recommended to treat 5 years.Buy NOLVADEX 20 on one of the best online dispensary.

· In the treatment of advanced forms, daily doses of between 20 and 40 mg are used at a rate of once or twice per day.

Pediatric population

The safety and efficacy of Nolvadex have not been established in children below 18 years of age. Currently available data are described in the sections Pharmacodynamic properties and Pharmacokinetic properties, but no recommendation on a posology can be made.Buy NOLVADEX 20 on one of the best online dispensary. Buy NOLVADEX 20 online In Australia

Warnings and precautions for use

Warnings

The risk of developing endometrial cancer and uterine sarcoma (mainly mixed Mullerian malignancies) is increased in the population treated with tamoxifen, compared to an untreated control population, and warrants careful gynecological monitoring. (see section Warnings and precautions for use Precautions for use).Buy NOLVADEX 20 on one of the best online dispensary. Buy NOLVADEX 20 online In Australia

PRIMARY prevention of breast cancer by tamoxifen (i.e. administration of the product to non-infected women) is not justified in the absence of efficacy demonstrated to date.

Due to the presence of lactose, patients with galactose intolerance, total lactase deficiency or glucose-galactose malabsorption syndrome (rare inherited diseases) should not take this medicine.

This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially ‘sodium free’.

In the literature, individuals who are poor metabolizers of CYP2D6 have been shown to have a lower plasma level of endoxifen, one of the most important active metabolites of tamoxifen (see section 5.2 ).Buy NOLVADEX 20 on one of the best online dispensary.

Concomitant treatments which inhibit CYP2D6 may lead to reduced concentrations of the active metabolite, endoxifen. Therefore, strong CYP2D6 inhibitors (e.g. paroxetine, fluoxetine, quinidine, cinacalcet, bupropion or rolapitant) should be avoided whenever possible during treatment with tamoxifen (see sections Interactions with other medicinal products and other forms of interaction. and Pharmacokinetic properties ).Buy NOLVADEX 20 on one of the best online dispensary.

Precautions for use

In all patients treated :

· Careful monitoring is recommended in patients at risk of thromboembolic events.

· Due to the risk of developing hypertriglyceridemia and pancreatitis, careful monitoring is recommended for patients with hypertriglyceridemia.

· The determination of estradiol receptor levels and / or progesterone in the tumor or its metastases, before starting treatment, has prognostic value (see Indications ).

· A complete gynecological examination, looking for a pre-existing endometrial abnormality is required before the initiation of treatment, then combined with at least annual monitoring.

· In addition, the patient will be warned of the need for a rapid consultation in the event of any abnormal vaginal bleeding: in-depth examinations should be performed. Indeed, an increase in the frequency of endometrial abnormalities (hyperplasias, polyps, cancers – see sections Warnings and precautions for use and Undesirable effects ) has been observed, probably linked to the estrogenic activity of tamoxifen on the endometrium.Buy NOLVADEX 20 on one of the best online dispensary.

· In case of microsurgical breast reconstruction delayed, Nolvadex can increase the risk of microvascular complications at the level of the flap.

· Perform monitoring of liver function during long-term treatment (over two years) (see section Preclinical safety data ).

In premenopausal women :

· Tamoxifen, as an anti-estrogen, can cause severe elevations of plasma estradiol concentrations (1000 to 2000 picograms per milliliter).

The premenopausal woman is thus exposed:

· To maintain its fertility, with a risk of pregnancy, theoretically against-indicated in patients with breast cancer,

– The occurrence of functional ovarian cysts, menometrorrhagia.

The onset of these side effects may require resting the ovary.Buy NOLVADEX 20 on one of the best online dispensary.

Pediatric population

The use of Nolvadex is not recommended in children and adolescents as safety and efficacy have not been established in this group of patients.

Pregnancy and breast feeding

Pregnancy

Due to a malformative effect of tamoxifen, found in animal experiments, it is advisable to eliminate, before any prescription and up to 9 months after stopping treatment, the possibility of pregnancy.

Provide effective contraception, not using an estrogen derivative (see section Preclinical safety data ).

Feeding with milk

Breast cancer contraindicates breastfeeding.

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